基于数据挖掘的冠心病PCI术后中医用药规律研究

Study on the law of traditional Chinese medicine after coronary heart disease PCI based on data mining

目的:探索中医治疗冠心病PCI术后的用药规律。方法:在中国知网、万方、维普、PubMed等数据库上广泛检索和收集冠心病PCI术后所用的中医处方并加以整理和统计分析,采用关联规则Apriori算法和复杂系统熵聚类分析等方法进行研究,得到相关结果。结果:最终纳入处方92条,高频次药物包括丹参、黄芪、川芎、当归、三七等;高频次药物组合包括“川芎,丹参”“丹参,黄芪”“赤芍,丹参”等;置信度较高的关联规则包括“川芎,党参→黄芪”“川芎,桃仁→红花”“桃仁→红花”“桃仁,当归→红花”等;新处方包括“木香,延胡索,五灵脂,鸡血藤,香附”“连翘,薏苡仁,苏木,川芎”“麦冬,党参,黄芪,五指毛桃,仙鹤草”等。结论:冠心病PCI术后证候要素复杂多样,气血痰瘀交杂而为病,辨证复杂,然其用药以益气活血、化痰通络、逐瘀散结为主,既以整体出发调养气血为本,又着眼于局部以通脉络为要,体现了中医在冠心病治疗中气血同调、痰瘀同治、治病求本的理念。

Objective:To explore the rule of Chinese medicine in the treatment of coronary heart disease after PCI.Methods:The Chinese medicine prescriptions used in PCI after coronary heart disease were collected and collected in China Knowledge Network,Wanfang,Weipu,PubMed and other databases for statistical analysis.The association rules Apriori algorithm and complex system entropy clustering were used to conduct research get relevant results.Results:92 prescriptions were finally included high-frequency drugs including Danshen,Astragalus,Chuanxiong,Angelica,Sanqi,etc.;high-frequency drug combinations include "Chuanxiong,Salvia miltiorrhiza"Salvia,Radix Astragali","Red Oak,Salvia" Etc.The higher confidence association rules include "Chuanxiong,Codonopsis-Huangqi","Chuanxiong,Taoren→red flower","Taoren→red flower","Taoren,Angelica→Rhonghua",etc.;the new prescription includes wWuxiang,Corydalis,Wulingzhi,spatholobus,fragrant,"Forsythia,Coix seed,Sumu,Chuanxiong","Oyster,Codonopsis? Astragalus,Wuzhi Maotao,Agrimony" and so on.Conclusion:The syndrome elements of coronary heart disease after PCI are complicated and diverse,and the blood and blood stasis are mixed and sick,and the syndrome differentiation is complicated.However,the medicine is used to replenish qi and activating blood circulation,resolving phlegm and collaterals,and phlegm and phlegm.Blood-based,and focus on the local to Tongluo network,reflecting the Chinese medicine in the treatment of coronary heart disease in the same blood and blood,taking care of the shackles,the idea of seeking treatment.