摘要
Propofol (2,6-diisopropylphenol) has been widely used in clinical surgery because of its fast induction and rapid recovery effects (Miller et al., 2014). Although the underlying mechanisms are still controversial, many studies have focused on the augmentation of GABA-induced inhibition and/or modulation of glycine receptor channel activity. However, inhibition of glutamatergic synaptic transmission may also contribute to general anesthesia. The effects of general anesthetics are significantly enhanced when glutamate receptor antagonists are co-administered (Ishizaki et al., 1996).
