喉软化症的发病机制及相关疾病研究进展

Research progress in the pathogenesis of laryngomalacia and related diseases

喉软化症是新生儿及婴幼儿喉喘鸣的最常见病因,其发病机制至今尚不清楚。目前多数研究认为与解剖异常、神经发育问题以及与胃食管反流、胎龄等相关,但任何一种发病学说都没有精确概述喉软化症的发病机制。近年最新研究表明此病是多种发病机制共同参与和共同作用的结果,现就近几年有关喉软化症的发病机制及相关疾病研究进展做一综述。

Laryngomalacia is the most common cause of stridor in neonates and infants,and its pathogenesis is still unclear. Currently the major view is that laryngomalacia is correlated with anatomic abnormalies, neurodevelopmental conditions, gastroesophageal reflux disease and gestational age ect. However, none of the theories can accurately summarize the pathogenesis of this disease .In recent years the latest research shows that laryngomalacia is the result of multiple pathogenesis .Here is to review progress in pathogensis and related diseases of laryngomalaciarecently.