老年2型糖尿病患者发生周围神经病的相关危险因素研究

Risk factors of peripheral neuropathy in elderly with type 2 diabetes mellitus

收集2017年9月至2018年5月就诊于首都医科大学附属北京天坛医院神经内科、内分泌科的≥60岁的2型糖尿病(T2DM)患者共165例。其中糖尿病周围神经病(DPN)组90例,无周围神经病组(NDPN)75例。记录两组患者临床资料、实验室检查等指标,进行单因素和多因素logistic回归分析DPN的危险因素。单因素分析显示,DPN组与NDPN组患者年龄、糖尿病病程、血红蛋白(Hb)、糖化血红蛋白(HbA1c)、餐后2h血糖(2hPBG)、HDL-C、医嘱依从性、家庭凝聚力比较,差异有统计学意义(P<0.05)。多因素logistic分析结果显示,HDL-C、Hb与DPN发病呈负相关(OR<1),病程、HbA1c、医嘱依从性差与DPN发病呈正相关(OR>1),提示糖尿病病程、HbA1c、HDL-C、Hb、医嘱依从性是老年T2DM患者并发DPN的影响因素。

One hundred and sixty-five patients with type 2 diabetes mellitus (T2DM) aged 60 years or older admitted to Beijing Tiantan Hospital from September 2017 to May 2018 were enrolled. There were 90 patients with diabetic peripheral neuropathy (DPN group) and 75 patients without DPN (NDPN group). The clinical data, laboratory tests and other indicators of the two groups were recorded, and the univariate and multivariate logistic analyses were performed. Univariate analysis showed that there was a significant difference in age, duration of diabetes, hemoglobin (Hb), glycosylated hemoglobin (HbA1c), 2-h post-prandial blood glucose (2 hPBG), high-density lipoprotein (HDL-C), treatment compliance and the relation-ship with family members between DPN and NDPN groups (P<0.05). Multivariate regression analysis revealed that the duration of diabetes, HbA1c, HDL-C, Hb and treatment compliance were independent risk factors for DPN in elderly patients with T2DM (P<0.05).