外泌体在结直肠癌领域的研究进展

Research progress on the functions of exosomes in colorectal cancer

外泌体是一类由多种细胞类型分泌的大小约40~100 nm,具有脂质双层膜结构的细胞外囊泡。它们天然存在于多种体液中,是细胞间通讯的重要介质。研究表明,外泌体与结直肠癌的发生发展、侵袭转移以及化疗耐药密切相关。本文综述了结直肠癌来源的外泌体在肠癌发病机制、诊断预后和治疗应用中的作用,以期为寻找结直肠癌治疗新靶点提供思路.

Exosomes are a class of extracellular vesicles that secreted by a variety of cells,with the length of 40-100 nm and a lipid bilayer membrane structure.They are often observed in multiple body fluids and are important mediators in intercellular communication.Several researches demonstrated that exosomes are closely linked to the development,invasion,metastasis,and drug resistance of colorectal cancer(CRC).In this review,the role of CRC-derived exosomes in the pathogenesis,diagnosis,prognosis and treatment of CRC were briefly summarized to provide a strategy for new therapeutic targets in CRC.