他汀药物应用与脑出血相关性的研究进展

The research advances of correlation between statin use and spontaneous intracerebral hemorrhage

他汀类药物,即3-羟基-3-甲基戊二酰辅酶A还原酶抑制剂,由于其在心脑血管缺血性疾病防治方面的有效性,已成为目前应用最广泛的降脂药之一.但一些临床数据表明,他汀类药物可能会增加脑出血风险;也有研究得出了相反的结论:他汀不仅不会增加出血风险,相反,脑出血患者继续应用他汀类药物还可以改善预后,降低病死率.因此,他汀应用与脑出血的关系,以及既往服用他汀药物的脑出血患者是否继续应用本类药物,还需要进一步的随机对照实验进行验证.我们对他汀药物应用与自发性脑出血相关性的研究进展进行综述.

Statins, 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors, are established first line treatments for hypercholesterolemia because of their proved efficacy. However, the results of several studies have raised concerns that statin use increases the risk of spontaneous intracerebral hemorrhage(ICH). At the same time, other researches make the adverse conclusion that statin use does not increase the risk of ICH, but improves clinical outcome and decreases the mortality after ICH. Additional randomized controlled trials are required to clarify the correlation between statin use and ICH, and whether to continue statin use after ICH. This paper reviews research advances of correlation between statin use and ICH.