基底前脑不同神经元对睡眠觉醒的调控

Different neurons in the basal forebrain regulate sleep-wake

基底前脑是位于大脑基底部的异质结构,参与对睡眠-觉醒、认知、意识、注意力等的调控.随着研究技术的进步,对基底前脑胆碱能神经元以及γ-氨基丁酸能神经元和谷氨酸能神经元功能的认识更加深入.文中总结了基底前脑不同神经元在睡眠觉醒调控中的作用.γ-氨基丁酸能神经元在促进觉醒中起关键作用,胆碱能神经元在睡眠-觉醒平衡中起重要作用,谷氨酸能神经元向其他神经元提供兴奋信号.

The basal forebrain is a heterogeneous structure at the base of the brain that participates in the regulation of sleep-wake, cognition, consciousness, and attention. Previous studies have suggested that these functions are mainly mediated by cholinergic neurons in the basal forebrain. With advances in research techniques, the understanding of basal forebrain cholinergic neurons, as well as GABAergic neurons and glutamatergic neurons, is deepened. The role of different neurons in the basal forebrain in the regulation of sleep-wake is summarized in this article. GABAergic neurons play a key role in promoting wakefulness, cholinergic neurons play an important role in sleep-wake homeostasis, and glutamatergic neurons provide excitation signals to other neurons.