2018年美国重症肌无力基金会科学会议热点与前沿

Introduction to the hotsports and forefront of 2018 Myasthenia Gravis Foundation of America′s Scientific Session

介绍了2018年度美国重症肌无力(MG)基金会科学会议的主要内容,显示出以下的研究趋势:国际上对MG的研究热点已由最常见的乙酰胆碱受体抗体阳性MG(AChR-MG)转为其他的亚型,特别是肌肉特异性受体酪氨酸激酶抗体阳性MG;胸腺切除术在整体AChR-MG群体有效,但在其他MG亚群效果不佳;现有治疗MG的药物还不能达到预期的疗效,因此层出不穷的新药研发业已成为MG研究的热门领域;基础研究方面更加重视探索参与MG发病的特异机制,包括抗原特异性B细胞乃至抗原特异性T细胞的研究.希望能对国内同仁有所参考.

The authors introduced the hotspots and forefront of 2018 Myasthenia Gravis Foundation of America′s Scientific Session, including the research forefront and trend of the following:International research hotspots in the myasthenia gravis (MG) had been changed from the most common acetylcholine receptor antibody positive MG (AChR-MG) into other subtypes, particularly muscle specific tyrosine kinase receptor antibody positive MG;The efficacy of thymectomy was effective in the whole AChR-MG group, but not in other MG subgroups;Existing drugs in MG treatment can not achieve the expected effect, so endless new drug development had become a hot field of MG research;In terms of basic research, more attention had been paid to exploring the specific mechanisms involved in MG pathogenesis, including the study of antigen specific B cells and even antigen specific T cells.