国内外ICU获得性衰弱研究现状的可视化分析

Visualization study on research status of Intensive Care Unit-acquired weakness in China and abroad

目的基于大数据背景下可视化分析方法对ICU获得性衰弱研究相关文献进行分析,整体把握ICU获得性衰弱治疗研究的现状,寻找ICU获得性衰弱相关研究的热点、不足,为临床研究提供参考。方法检索PubMed、Embase、Web of Science、Cochrane Library外文数据和中国生物医学文献数据库、万方、CNKI、维普中文数据库自建库至2018年9月1日的文献,纳入所有中英文发表的ICU获得性衰弱相关研究。应用Endnote软件,人工去重后采用BICOMB 2软件对文献主要信息进行提取并生成共现矩阵,然后使用Ucinet 6.0主要信息社会网络关系图谱,最后使用gCluto 1.0软件绘制可视化图谱。结果共提取文献1 053篇,自1993年发表第1篇文献后,到2006年学者才开始关注本病。全球有41个国家和地区均有不同程度的合作研究,其中美国累积发文量223篇(21.18%)。综述、系统评价类文章多达259篇(24.6%),临床试验、观察、队列等研究相对较少。48名作者参与10篇及以上的论文发表,而发文量1篇作者多达2 080名(69.15%)。文献发表在385种期刊上,载文量>10篇期刊仅14种(3.64%),累积载文量450篇(42.73%)。发表文献的引用频率相对较低,被引频次>50次文献仅80篇(7.60%)。关键词可视化图谱显示ICU获得性衰弱研究热点有病理生理机制、诊断、康复治疗。结论ICU获得性衰弱相关研究尚处于初步研究阶段,其深度、广度还有待于进一步挖掘,尚需开展更多的多中心、单中心临床研究探讨ICU获得性衰弱的诊断、相关危险因素、治疗措施、预防及其对患者转归及生活质量的影响。

Objective To analyze the relevant literatures of research on Intensive Care Unit-acquired weakness (ICU-AW) by visualization analysis method based on the large data visualization analysis background, understand the current researches on ICU-AW treatment as a whole, and find out the hot spots and shortcomings of ICU-AW related researches, so as to provide reference for clinical researches. Methods To retrieve the PubMed, Embase, Web of Science, the Cochrane Library, and the Chinese Biomedical Literature Database, WanFang, CNKI and VIP Chinese databases from the databases' establishment data to September 1st, 2018. All published Chinese and English articles about ICU-AW were included. Endnote software was used to extract the main contents of literatures and generate co-occurrence matrix by BICOMB 2 software after manual de-duplication. Then Ucinet 6.0 was used to map the main information social network graph. Finally, gCluto 1.0 was used to draw the visualization graphs. Results A total of 1 053 literatures were extracted. Since the publication of the first one in 1993, scholars began to pay attention to the disease in 2006. A total of 41 countries and regions all over the world had collaborative research in varying levels, of which 223 (21.18%) have been published in the United States. Up to 259 articles (24.6%) were summaries and systematic reviews, while few studies were clinical trials, observation and cohorts. Totally 48 authors participated in the publication of 10 or more papers, and the number of authors who had published one article was 2 080 (69.15%). The literatures were published in 385 journals. Only 14 journals (3.64%) contained more than 10 articles, and 450 journals (42.73%) accumulated. The citation frequency of published literatures was relatively low, and only 80 (7.60%) of them were cited more than 50 times. The visualization graph of key words showed that the research hot spots of ICU-AW included pathophysiological mechanism, diagnosis and rehabilitation treatment. Conclusions The research on ICU-AW is still in the preliminary stage, and its depth and breadth need to be further explored. More multi-center and single-center clinical studies are needed to explore the diagnosis, related risk factors, treatment measures, prevention of ICU-AW and its impact on patients' outcomes and quality of life.