思密达配伍庆大霉素治疗异位妊娠合并宫颈HPV E6/E7mRNA阳性使用甲氨蝶呤致口腔溃疡的临床研究

Clinical effect of smecta combined with gentamicin in the treatment of oral ulcer caused by methotrexate used for ectopic pregnancy with cervical HPV E6/E7 mRNA positive

目的通过比较思密达配伍庆大霉素在治疗异位妊娠合并宫颈HPVE6/E7mRNA阳性患者使用甲氨蝶呤致口腔溃疡的疗效分析,探讨其治疗效果。方法选取2016年1月1日~2018年1月1日在本院因异位妊娠行甲氨蝶呤保守治疗后出现口腔溃疡的患者172例,分为三组,A组宫颈HPVE6/E7mRNA阴性(n=81),B组宫颈HPVE6/E7mRNA阳性(n=69),两组均采用思密达配伍庆大霉素治疗因甲氨蝶呤保守治疗导致的口腔溃疡,C组宫颈HPVE6/E7mRNA阳性及阴性均存在(n=22),但采用期待治疗,不进行医疗处理。观察三组口腔溃疡恢复及疼痛评分情况。结果A组治疗的总有效率为93.83%,B组治疗的总有效率为88.41%,C组治疗的总有效率为45.45%,总有效率A组>B组>C组,差异有统计学意义(P<0.05);三组疼痛评分:A组<B组<C组,差异均有统计学意义(P<0.05)。结论甲氨蝶呤治疗异位妊娠合并宫颈HPVE6/E7mRNA阳性患者所致口腔溃疡,使用思密达配伍庆大霉素涂抹患处对口腔溃疡的疗效明显。

Objective To explore the clinical effect of Smecta combined with gentamicin in the treatment of oral ulcer caused by methotrexate used for ectopic pregnancy with cervical HPV E6/E7 mRNA positive.Methods 172 patients with oral ulcers after conservative treatment with methotrexate in ectopic pregnancy were divided into 3 groups.Group A was negative in HPV E6/E7 mRNA(n=81),group B was positive in HPV E6/E7 mRNA(n=69),and Smecta combined with gentamicin were used in both groups for the treatment of oral ulcer caused by conservative treatment by methotrexate,and both positive and negative HPV E6/E7 mRNA was observed in group C(n=22),but they were treated with expectant treatment instead of medical treatment.The oral ulcer recovery and pain scores were observed.Results The total effective rate of treatment in group A was 93.83%,the total effective rate in group B was 88.41%,the total effective rate in group C was 45.45%,and the differences(group A>group B>group C)were statistically significant(P<0.05);the differences of pain score(group A<group B<group C)were significant among the three groups(P<0.05).Conclusion The clinical effect of Smecta combined with gentamicin in the treatment of oral ulcer caused by methotrexate used for ectopic pregnancy with cervical HPV E6/E7 mRNA positive is significant.