盐酸美金刚治疗老年帕金森痴呆的临床疗效及对认知功能的影响分析

Clinical Efficacy of Memantine Hydrochloride in the Treatment of Elderly Patients with Parkinson’s Disease and Its Impact on Cognitive Function

目的老年帕金森痴呆患者通过盐酸美金刚进行治疗,对患者治疗后的临床治疗效果、不良情况的发生情况进行研究,将该方法与另一种方法的治疗效果进行比较,形成对照,评价盐酸美金刚的治疗效果。方法该次研究从该院在2017年3月—2018年3年收治的老年帕金森痴呆患者中随机抽取出60例患者进行试验研究,将其当成该次研究的研究对象,将所有患者按照随机化方法分成两组,每组由30例患者组成,一组患者通过服用盐酸美金刚治疗,叫做观察组,一组患者通过盐酸多奈哌齐进行医治,叫做对照组,将两组患者的治疗总有效率、不良情况的发生率进行研究比较,从而将老年帕金森痴呆患者通过盐酸美金刚治疗效果进行评价,为临床中的老年帕金森痴呆患者提供更加有力的治疗依据。结果观察组患者通过盐酸美金刚治疗之后,获得的治疗总有效率为90.0%(27/30),而对照组患者通过盐酸多奈哌齐进行治疗之后,获得的治疗总有效率为60.0%(18/30),两组之间的差异有统计学意义(χ^2=15.249 6,P<0.05);观察组患者的不良反应的发生情况为:发生头痛、头晕、恶心、失眠情况的患者各有1例,不良情况的发生概率为13.3%(4/30),对照组患者发生头痛、头晕/恶心、失眠情况的患者各有3例、2例、2例、3例,不良情况的发生概率为33.3%(10/30),差异有统计学意义(χ^2=16.349 1,P<0.05)。结论老年帕金森痴呆患者通过服用盐酸美金刚进行治疗,可以获得优良的治疗效果,并且治疗之后可以获得较低的不良情况发生率,值得在临床中推广以及应用。

Objective The elderly patients with Parkinson's dementia were treated with memantine hydrochloride to study the clinical treatment effect and the occurrence of adverse conditions after treatment. The method was compared with the therapeutic effect of another method to form a control. The therapeutic effect of memantine hydrochloride was evaluated. Methods In this study, randomly selected 60 patients from the elderly patients with Parkinson's dementia who were admitted to the hospital from March 2017 to March 2018, and conducted a trial study. All subjects were di-vided into two groups according to randomization method. Each group consisted of 30 patients. One group of patients was treated with memantine hydrochloride, which was called observation group. One group of patients was treated with donepezil hydrochloride, as the control group. The total effective rate and the incidence of adverse events were com-pared between the two groups of patients, so that the elderly patients with Parkinson's dementia were evaluated by the effect of memantine hydrochloride treatment, which provided a more powerful treatment basis for the elderly patients with Parkinson's disease. Results The total effective rate of treatment was 90.0%(27/30) after treatment with meman-tine hydrochloride in the observation group, and the total effective rate of treatment was 60.0%(18/30) after treatment with donepezil hydrochloride in the control group, the difference between the two groups was statistically significant(χ^2= 15.249 6,P<0.05);the incidence of adverse reactions in the observation group was: patients with headache, dizziness, nausea, insomnia had 1 case, the incidence of adverse events was 13.3%(4/30). In the control group, there were 3 cases, 2 cases, 2 cases, and 3 cases of headache, dizziness, nausea, and insomnia. The probability of adverse events was 33.3%(10/30), the difference was statistically significant (χ^2=16.349 1,P <0.05). Conclusion Elderly patients with Parkinson's dementia can achieve excellent therapeutic effects by taking memantine hydrochloride treatment, and can obtain a lower incidence of adverse events after treatment, which is worthy of promotion and application in the clinic.