粪菌移植的临床进展

Clinical Progress of Fecal Bacteria Transplantation

粪菌移植(FMT)是一种直接改变受者肠道微生物群,使其组成正常化,获得治疗效果的方法。肠道微生物群的生态失调涉及到一些胃肠道疾病及肠外疾病。目前的研究表明,FMT在治疗难辨梭状芽孢杆菌(艰难梭菌)感染(CDI)、炎症性肠病(IBD)、肠易激综合征(IBS)和肝性脑病(HE)等疾病方面有一定的效果。该文就FMT的发展历程、临床应用以及存在的问题和展望等方面作一综述。

Fecal bacterial transplantation (FMT) is a method to directly change the intestinal microbiota of the recipi-ent, normalize its composition, and obtain therapeutic effects. The dysbiosis of the gut microbiota involves some gas-trointestinal diseases and extraintestinal diseases. Current research indicates that FMT is used in the treatment of dis-eases such as Clostridium difficile (C. difficile) infection (CDI), inflammatory bowel disease (IBD), irritable bowel syn-drome (IBS) and hepatic encephalopathy (HE), with a certain effect. This article reviews the development history, clinical application, existing problems and prospects of FMT.