术前强化他汀治疗对于高龄冠心病患者冠脉介入治疗预后效果的影响分析

Effect of Preoperative Intensive Statin Therapy on Prognosis of Elderly Patients with Coronary Heart Disease Undergoing Coronary Intervention

目的探究术前强化他汀治疗对于高龄冠心病患者冠脉介入治疗预后效果的影响。方法病例选取2017年1—12月该院接收的90例高龄冠心病患者为对象开展研究,根据治疗方式不同分为参照组与研究组,每组各45例,给予参照组冠脉介入治疗,给予研究组冠脉介入术前强化他汀治疗。对比两组患者的实验室有关指标、血脂水平与不良事件,进行统计分析。结果研究组患者术后1 d的HDL-C水平、TG水平与TC水平(1.27±0.19)mmol/L,(1.43±0.57)mmol/L,(4.48±0.69)mmol/L与参照组(1.29±0.20)mmol/L,(1.47±0.64)mmol/L,(4.69±0.92)mmol/L,差异无统计学意义(t=0.754 7、0.356 7、0.626 8,P>0.05)。研究组患者术后1 d的TNI水平、CRP水平与CK-MB水平(0.08±0.02)μg/L、(8.31±3.47)mg/L、(15.18±3.74)U/L改善均优于参照组(0.17±0.03)μg/L,(12.09±5.89)mg/L,(20.67±7.18)U/L,差异有统计学意义(t=5.894 3、5.995 7、6.378 3,P<0.05)。研究组患者术后1年的不良事件发生率(4.44%)低于参照组(17.78%),差异有统计学意义(χ^2=4.050 0,P<0.05)。结论高龄冠心病患者行冠脉介入治疗前,给予强化他汀治疗,有效抑制术后炎性反应,促进血脂水平恢复,预防心血管不良事件,具有显著的治疗效果。

Objective To investigate the effect of preoperative intensive statin therapy on the prognosis of coronary intervention in elderly patients with coronary heart disease. Methods A total of 90 elderly patients with coronary heart disease received from this hospital from January to December 2017 were enrolled and were divided into a reference group and a study group according to different treatment methods. Each group consisted of 45 patients, and the reference group was given coronary artery. Interventional therapy was given to the study group to strengthen statin therapy before coronary intervention. The laboratory-related indicators, blood lipid levels, and adverse events were compared between the two groups for statistical analysis. Results The HDL-C level, TG level and TC level study group (1.27± 0.19)mmol/L,(1.43±0.57)mmol/L,(4.48±0.69)mmol/L and reference group (1.29±0.20)mmol/L,(1.47±0.64)mmol/L,(4.69± 0.92)mmol/L in the study group at 1 d after operation. The differences were not (t=0.754 7、0.356 7、0.626 8,P>0.05). Month after operation and 1 d after poerabon,the TNI level, CRP level and CK-MB level (0.08±0.02)μg/L,(8.31±3.47)mg/L,(15.18±3.74)U/L were better in the study group than in the reference group (0.17±0.03)μg/L,(12.09±5.89)mg/L,(20.67± 7.18)U/L. The differences were statistically significant (t=5.894 3、5.995 7、6.378 3,P<0.05). The incidence of adverse events in the study group (4.44%) was lower than that in the reference group (17.78%) after 1 year and the differece was statistically significant (χ^2 =4.050 0,P<0.05). Conclusion Before treatment of coronary artery disease in elderly patients with coronary artery disease, intensive statin therapy can effectively inhibit postoperative inflammatory reaction, promote blood lipid level recovery, prevent cardiovascular adverse events, and have significant therapeutic effects.