洛铂与顺铂对宫颈癌患者的放疗增敏效果及不良反应的比较

Sensitizing effects and adverse reactions of lobaplatin versus cisplatin used in radiotherapy for patients with cervical cancer:a comparative study

目的 比较洛铂与顺铂对宫颈癌患者的放疗增敏疗效及不良反应。方法 将80例中晚期宫颈癌患者分为研究组和对照组,每组40例,研究组采用洛铂联合放疗,对照组采用顺铂联合放疗。比较两组患者的近期疗效及不良反应。结果 两组患者完全缓解率及总有效率差异均无统计学意义(均P>0.05),但研究组患者Ⅰ~Ⅱ度、Ⅲ~Ⅳ度的白细胞下降率、消化道反应发生率低于对照组(P<0.05),Ⅰ~Ⅱ度血小板下降率高于对照组(均P<0.05)。结论 洛铂与顺铂对宫颈癌患者的放疗增敏效果相当,但洛铂毒副反应更小。

Objective To compare the sensitizing efficacy and adverse reactions of lobaplatin versus cisplatin used in radiotherapy for patients with cervical cancer. Methods Eighty patients with middle-stage and advanced cervical cancer were divided into study group and control group,with 40 cases in each group.The study group received lobaplatin combined with radiotherapy,while the control group received cisplatin combined with radiotherapy.Short-term efficacy and adverse reactions were compared between the two groups. Results No statistically significant differences were found between the two groups in rate of complete remission or total effective rate(all P >0.05),but the study group exhibited a lower rate of WBC decline of grade Ⅰ-Ⅱ or Ⅲ-Ⅳ,a lower incidence rate of gastrointestinal reactions ,and a lower rate of platelet decline of grade Ⅰ-Ⅱ as compared with the control group(all P <0.05). Conclusion Lobaplatin is similar to cisplatin in sensitizing effects of radiotherapy for patients with cervical cancer,but lobaplatin has minor toxic and side effects.