妇科手术对抗苗勒管激素及卵巢储备功能的影响

The Effect of Gynecological Surgery on Ovarian Reserve Function with Anti-Müllerian Hormone

随着妇科手术方式层出不穷,尤其是微创手术的广泛开展,如何最大限度地保护卵巢储备功能是医患共同关心的话题。卵巢储备功能反映女性的生育能力,是指卵巢内存在的可受精的卵母细胞的数量和质量,评估指标有年龄、基础卵泡刺激素、雌二醇、黄体生成激素、抑制素B、基础窦状卵泡数和卵巢体积等,但是都存在一定的局限性。抗苗勒管激素(anti-Müllerian hormone,AMH)由卵巢的颗粒细胞分泌,在整个月经周期保持相对稳定,测定不受月经周期影响,是预测卵巢储备的可靠指标。综述临床中不同妇科手术对卵巢储备功能的影响。

With more and more gynecological operation methods, especially the extensive development of minimally invasive surgery, how to protect the ovarian reserve function to the maximum is a common topic for doctors and patients. Ovarian reserve reflects a woman′s fertility and refers to the quantity and quality of fertilizable oocytes in the ovary, as measured by age, basal follicle stiminulating hormone, estradiol, luteinizing hormone, and Inhibin B, the number of basal antral follicles and the volume of ovaries, but there are some limitations. Anti-Müllerian hormone (AMH), which is secreted by the ovarian granulosa cells, remains relatively stable throughout the menstrual cycle and is not affected by the menstrual cycle, thus AMH is a reliable predictor of ovarian reserve. This article reviews the effects of different gynecological operations on ovarian reserve.