多囊卵巢综合征合并心血管疾病预测标记物的研究进展

Advances in the Study of Markers for Predicting Cardiovascular Disease Associated with Polycystic Ovary Syndrome

多囊卵巢综合征(PCOS)是育龄期妇女最常见的内分泌疾病之一。PCOS患者除可见B型超声下卵巢呈多囊样改变、稀发排卵或无排卵等,尚伴有高雄激素血症、胰岛素抵抗、脂代谢异常等情况。同时,其与多种疾病如肥胖、2型糖尿病、心血管疾病(CVD)及抑郁症等均有密切关系。其中,PCOS合并CVD逐渐受到学界关注。然而,其具体发病机制目前尚不明确,同时亦无特定的相关筛查指标,导致不能及时阻断病情的发展。因此,寻找PCOS合并CVD预测标记物,对其及时诊断及干预,成为临床中提高PCOS妇女生存质量、降低其发病率的重要方法之一。现总结近年PCOS合并CVD相关预测标记物,包括超敏C反应蛋白、同型半胱氨酸、半乳糖凝集素3、血脂参数和人体测量参数等,对其性质及预测效能进行综述。

Polycystic ovary syndrome (PCOS) is one of the most common endocrine diseases in women of childbearing age. In addition to polycystic ovarian changes, sparse ovulation or anovulation under B-mode ultrasonography, hyperandrogenism, insulin resistance and abnormal lipid metabolism and so on are also observed in the patients. At the same time, it is closely related to many diseases such as obesity, type 2 diabetes, cardiovascular disease (CVD) and depression. Among them, PCOS combined with CVD has gradually attracted academic attention. However, its specific pathogenesis is not yet clear, and there are no specific related screening indicators, which can not block the development of the disease in time. Therefore, to find out the predictors of PCOS with CVD and to make timely diagnosis and intervention is one of the important methods to improve the quality of life and reduce the incidence of PCOS in clinic. In this paper, we summarize the predictive markers related to PCOS complicated with CVD in recent years, including hypersensitive C-reactive protein, homocysteine, galectin-3, blood lipid parameters and anthropometric parameters, etc., and summarize their properties and predictive efficacy.