肾康注射液不良反应文献分析

Literature Analysis of the Adverse Reactions Induced by Shenkang Injection

目的促进肾康注射液的临床合理用药。方法以“肾康注射液”“不良反应”“过敏”为主题词,检索中国知网、万方、维普数据库(2008年1月1日至2018年7月24日)有关使用肾康注射液致不良反应的文献,并进行统计和分析。结果检索到相关文献22篇,提取个案病例26例;不良反应发生人群以中老年人(45岁及以上)居多,原患疾病主要为肾脏相关疾病,不良反应多发于用药后0.5 h内,且累及多个系统/器官,预后均良好。结论静脉滴注肾康注射液0.5 h内应加强监护,以减少或避免药品不良反应。

Objective To promote the safe use of Shenkang Injection in the clinic.Methods With ″Shenkang Injection″″adverse reaction″ and ″allergy″ as the keywords,the literature of adverse drug reaction(ADRs) induced by Shenkang Injection in the CNKI,Wanfang and VIP databases from January 1,2008 to July 24,2018 was retrieved and analyzed.Results Totally 22 relevant studies were retrieved,and 26 individual cases were extracted.ADRs majorly occurred among middle-aged and elderly patients,most of whom had been suffering from kidney-related diseases.Most of the ADRs occurred within 0.5 h after treatment,and involved many systems/organs.The prognosis was good.Conclusion The monitoring of Shenkang Injection should be strengthened within 0.5 h after intravenous drip to reduce or avoid ADRs.