二甲苯致家兔耳肿胀急性炎症模型的建立

Establishment of Acute Inflammation Rabbit Models with Ear Edema Induced by Dimethylbenzene

以家禽市场采购的家兔为材料,用不同剂量的二甲苯均匀涂布于家兔左耳耳廓上下两面,30min后,测定不同剂量二甲苯处理家兔耳廓的重量变化,计算肿胀率,观察耳廓的形态学变化.实验结果表明,随着二甲苯剂量的增加,家兔耳廓的肿胀呈上升趋势,二甲苯致家兔耳肿胀率最高的剂量为30μL,超过该剂量,肿胀率则呈下降趋势.

Rabbits purchased from poultry market were used as materials,and different doses of dimethylbenzene were evenly applied to the upper and lower sides of rabbits′ left auricle.Thirty minutes later,weight changes of auricle of rabbits treated with different doses of dimethylbenzene were measured,then calculate the swelling rate and observe morphological changes of auricle.The results show that with the increase of dimethylbenzene dosage,the swelling of rabbits′ auricle showed an upward trend,the optimum dose of dimethylbenzene induced ear swelling was 30 μL.Thereafter,With the increase of dimethylbenzene dosage,the swelling rate decreased.