急性心肌梗死患者冠脉介入治疗前后尿酸变化及临床意义

Changes of Uric Acid before and after Coronary Intervention in Patients with Acute Myocardial Infarction and Its Clinical Significance

目的探讨急性心肌梗死患者冠脉介入治疗(PCI)前后尿酸(UA)变化及临床意义。方法选择心血管内科2018年1—12月确诊的急性ST段抬高型心肌梗死(STEMI)患者56例(AMI组),年龄50~75岁,平均(65.80±11.78)岁,对照组40例,年龄45~75岁,平均(62.55±12.47)岁,检测AMI组患者入院时及PCI治疗后血清尿酸水平进行比较分析。结果AMI组患者尿酸水平(364.92±93.26)μmol/L明显高于对照组(320.82±70.59)μmol/L,差异有统计学意义(t=2.429,P<0.05),AMI患者PCI治疗后尿酸水平(302.64±74.30)μmol/L较入院时显著下降,差异有统计学意义(t=8.664,P<0.01)。结论尿酸与AMI的发生相关,血清尿酸指标可以作为AMI患者诊断及PCI疗效观察的辅助指标。

Objective To investigate the changes and clinical significance of uric acid(UA)before and after coronary intervention(PCI)in patients with acute myocardial infarction.Methods Select the acute ST-segment elevation myocardial infarction diagnosed by Cardiovascular Medicine from January to December 2018.(STEMI)56 patients(AMI group),50~75 yearsold,mean(65.80±11.78)years old,40 patients in the control group,45~75 yearsold,mean(62.55±12.47)years old,when the patients in the AMI group were admitted to the hospital And serum uric acid levels after PCI treatment were compared and analyzed.Results The uric acid level(364.92±93.26)μmol/L in the AMI group was significantly higher than that in the control group(320.82±70.59)μmol/L,the difference was statistically significant(t=2.429,P<0.05),uric acid level after PCI treatment in patients with AMI(302.64±74.30)μmol/L was significantly lower than that at admission,the difference was statistically significant(t=8.664,P<0.01);Conclusion Urinary acid is associated with the occurrence of AMI,serum uric acid index can be used as a diagnosis of AMI patients and PCI observation auxiliary indicator.