复方甘草酸苷递减疗法联合依巴斯汀治疗慢性荨麻疹疗效分析

Therapeutic Effect of Compound Glycyrrhizin Depressive Therapy Combined with Ebastine on Chronic Urticaria

目的分析复方甘草酸苷递减疗法联合依巴斯汀治疗慢性荨麻疹的疗效。方法将2015年1月—2018年12月来该院治疗的112例慢性荨麻疹患者设为研究对象。基于随机数字法,均分并成立对照组与治疗组,每组56例。对照组采用依巴斯汀片治疗,治疗组就对照组基础上增加复方甘草酸苷片递减治疗。对比评价两组临床疗效情况及复发情况。结果治疗后,治疗组患者总有效率为98.21%,显著优于对照组91.07%,对比结果数据差异有统计学意义(χ^2=1.409,P<0.05);治疗组复发情况(UAS7评分低于14分者4例,总复发率1.79%)显著优于对照组(UAS7评分低于14分者14例,总复发率10.71%),对比结果数据差异有统计学意义(χ^2=1.907,P<0.05)。结论复方甘草酸苷递减疗法联合依巴斯汀治疗慢性荨麻疹疗效理想,且能进一步减小病症的复发情况,故该方法值得临床推广。

Objective To analyze the efficacy of compound glycyrrhizin depressive therapy combined with ebastine in the treatment of chronic urticaria.Methods 112 patients with chronic urticaria who were treated in our hospital from January 2015 to December 2018 were enrolled.Based on the random number method,the control group and the treatment group(56 cases in each group)were divided and established.The control group was treated with Ebastine tablets,and the treatment group increased the compound glycyrrhizin tablets on the basis of the control group.The clinical efficacy and recurrence of the two groups were compared and evaluated.Results After treatment,the total effective rate of the treatment group was 98.21%,which was significantly better than that of the control group(91.07%).the difference was statistically significant(χ^2=1.409,P<0.05).The recurrence of the treatment group(UAS7 score was less than 14 points.In 4 cases,the total recurrence rate was 1.79%),which was significantly better than the control group(14 cases with UAS7 score lower than 14 points,total recurrence rate was 10.71%).the difference was statistically significant(χ^2=1.907,P<0.05).Conclusion Compound glycyrrhizin declining therapy combined with ebastine is effective in the treatment of chronic urticaria,and can further reduce the recurrence of the disease,so this method is worthy of clinical promotion.