探讨甲泼尼龙在儿童难治性支原体肺炎治疗中的临床疗效

Investigation on the Clinical Efficacy of Methylprednisolone in the Treatment of Refractory Mycoplasmal Pneumonia in Children

目的分析小儿难治性支原体肺炎行甲泼尼龙的治疗效果。方法纳入该院于2013年4月—2018年4月期间行支原体抗体诊断,确诊的难治性支原体肺炎患儿64例,以随机数字表法的形式将64例患儿平均分为研究组和对照组,每组32例,两组均予以阿奇霉素序贯治疗联合头孢,在此基础上研究组加行甲泼尼龙,对比两组治疗总有效率以及临床退热时间、咳嗽缓解时间和肺部阴影消散时间。结果研究组治疗后总有效率90.60%高于对照组68.75%,组间对比差异有统计学意义(χ^2=4.730,P<0.05);研究组治疗后,退热用时(5.2±1.5)d、咳嗽改善用时(7.5±1.9)d以及肺部阴影消退用时(8.8±2.2)d短于对照组(7.2±2.3)d、(9.3±3.0)d、(11.9±4.0)d,组间两组比较差异有统计学意义(t=4.120、2.867、3.841,P=0.000、0.006、0.000<0.05)。结论甲泼尼龙应用于难治性支原体肺炎患儿中,能够改善临床指标,提升总有效率。

Objective To analyze the therapeutic effect of methylprednisolone in children with refractory mycoplasmal pneumonia.Methods Sixty-four children with refractory mycoplasmal pneumonia diagnosed in our hospital from April 2013 to 2018 April were enrolled.The 64 patients were divided into study group and control group by random number table.All 32 cases were treated with azithromycin sequential therapy combined with cephalosporin.On the basis of this,the study group was treated with methylprednisolone,and the total effective rate as well as clinical antipyretic time,cough remission time and lung shadow dissipation time were compared.Results The total effective rate was 90.60%in the study group and 68.75%in the control group.The comparison between the two groups was statistically significant(χ^2=4.730,P<0.05).After treatment,the study group received antipyretic time(5.2±1.5)days,cough improvement time(7.5±1.9)d and lung shadow regression time(8.8±2.2)d shorter than the control group(7.2±2.3)d,(9.3±3.0)d,(11.9±4.0)d,between the two groups,the different was statistically significant(t=4.120,2.867,3.841,P=0.000,0.006,0.000<0.05).Conclusion Methylprednisolone can improve clinical indicators and improve total efficiency in children with refractory mycoplasmal pneumonia.