坎地沙坦联合来氟米特对糖尿病肾病患者肾功能及肾间质纤维化指标的影响

Effects of candesartan combined with leflunomide on renal function and renal interstitial fibrosis in patients with diabetic nephropathy

目的探索坎地沙坦联合来氟米特对糖尿病肾病患者肾功能及肾间质纤维化指标的影响。方法选取我院收治的100例糖尿病肾病患者为研究对象,采用数据库随机分组方法将其分为观察组和对照组,各50例。观察组采用坎地沙坦联合来氟米特治疗,对照组采用缬沙坦治疗。比较两组治疗效果。结果治疗后,两组Cys C、BUN、hs-CRP、UACR、24 h尿蛋白定量、CTGF、TGF-β1、LN、FN水平均降低,且观察组低于对照组(P<0.05)。结论坎地沙坦联合来氟米特治疗糖尿病肾病患者的效果显著,可改善肾间质纤维化和肾功能。

Objective To explore the effects of candesartan combined with leflunomide on renal function and renal interstitial fibrosis in patients with diabetic nephropathy. Methods One hundred patients with diabetic nephropathy were selected as the research objects and divided into observation group and control group accroding to database random grouping method, with 50 cases in each group. The observation group was treated with candesartan combined with leflunomide, while the control group was treated with valsartan. The therapeutic effects of the two groups were compared. Results After treatment, the levels of Cys C, BUN, hs-CRP, UACR, 24-hour urinary protein quantity, CTGF, TGF-β1, LN and FN in both groups decreased, and those in the observation group were lower than the control group (P<0.05). Conclusion Candesartan combined with leflunomide is effective in treating diabetic nephropathy, which can improve renal interstitial fibrosis and renal function.