不同免疫检验方法检测乙肝病毒感染血清标志物的效果

Effect of different immunoassay methods on detecting serum markers of hepatitis B virus infection

目的评价不同免疫检验方法检测乙肝病毒感染血清标志物的效果。方法选择2018年1月至2019年3月于本院接受治疗的乙肝病毒感染患者110例,采用数字随机分组法将其分为两组,各55例。对照组接受酶联免疫吸附试验检测,观察组接受化学发光免疫分析法检测。比较两组的血清标志物阳性检出情况和检测成本。结果观察组的HBsAg、HBeAg及HBeAb阳性检出率均显著高于对照组,差异具有统计学意义(P<0.05)。观察组的检测成本显著高于对照组,差异具有统计学意义(P<0.05)。结论化学发光免疫分析法检测乙肝病毒感染血清标志物具有良好的诊断效果,HBsAg、HBeAg及HBeAb阳性检出率均较高,值得广泛应用于临床检测中。

Objective To evaluate the effect of different immunoassay methods on detecting serum markers of hepatitis B virus infection. Methods A total of 110 patients with hepatitis B virus infection treated in our hospital from January 2018 to March 2019 were divided into two groups by digital random grouping method, with 55 cases in each group. The control group was tested by enzyme linked immunosorbent assay, and the observation group was tested by chemiluminescence immunoassay. The positive detection of serum markers and detection cost were compared between the two groups. Results The positive rates of HBsAg, HBeAg and HBeAb in the observation group were significantly higher than those in the control group, the differences were statistically significant(P<0.05). The detection cost in the observation group was significantly higher than that in the control group, the difference was statistically significant(P<0.05). Conclusion Chemiluminescence immunoassay has a good diagnostic effect for serum markers of hepatitis B virus infection, and the positive rates of HBsAg, HBeAg and HBeAb are higher. It is worthy of being widely used in clinical detection.