门冬胰岛素联合维生素D治疗妊娠期糖尿病的效果

Effect of insulin asparagus combined with vitamin D in the treatment of gestational diabetes mellitus

目的研究门冬胰岛素联合维生素D治疗妊娠期糖尿病的效果。方法选择2016年1月至2018年12月我院收治的52例妊娠期糖尿病患者作为研究对象,用抽签法将患者随机分为对照组与观察组,各26例。对照组仅采用门冬胰岛素治疗,观察组采用门冬胰岛素联合维生素D3肌肉注射。比较两组患者的治疗效果。结果观察组的治疗总有效率显著高于对照组,差异具有统计学意义(P<0.05);治疗后,两组患者的PBG、FINS、FBG水平均低于治疗前,HOMA-β明显高于治疗前,且观察组均优于对照组(P<0.05);治疗后,两组患者的血磷、血清iPTH水平及钙磷乘积均明显降低,且观察组低于对照组(P<0.05);治疗后,两组患者的血钙水平比较,差异无统计学意义(P>0.05);两组患者的顺产率、剖宫产率、新生儿窒息率、新生儿死胎率、巨大儿率、早产儿率及高胆红素血症率比较,差异无统计学意义(P>0.05)。结论门冬胰岛素联合维生素D能显著提高胰岛素的敏感性,有效控制血糖,纠正钙磷代谢的紊乱,改善妊娠结局。

Objective To study the effect of insulin asparagus combined with vitamin D in the treatment of gestational diabetes mellitus. Methods A total of 52 patients with gestational diabetes mellitus admitted in our hospital from January 2016 to December 2018 were selected as the study objects and randomly divided into control group and observation group by draw lots method, with 26 cases in each group. The control group was treated with insulin asparagus only, while the observation group was treated with insulin asparagus combined with intramuscular injection of vitamin D3. The treatment effects between the two groups were compared. Results The total effective rate of treatment in the observation group was significantly higher than that in the control group (P<0.05). After treatment, the levels of PBG, FINS and FBG in both groups decreased significantly, and HOMA-β increased significantly, and those in the observation group were better than the control group (P<0.05). After treatment, the levels of blood phosphorus and serum iPTH and calcium-phosphorus product in the two groups decreased significantly, and those in the observation group were lower than the control group (P<0.05). After treatment, there was no significant difference in the level of serum calcium between the two groups after treatment (P>0.05). There were no significant differences in the rates of natural childbirth, cesarean section, neonatal asphyxia, neonatal stillbirth, macrosomia, premature birth and hyperbilirubinemia between the two groups (P>0.05). Conclusion Insulin asparagus combined with vitamin D can significantly improve insulin sensitivity, effectively control blood glucose, correct the disorder of calcium and phosphorus metabolism, and ameliorate pregnancy outcomes.