头孢泊肟酯在儿科应用研究进展

Research progress of Cefpodoxime proxetil application in pediatrics

头孢泊肟酯(Cefpodoxime proxetil,CPDX-PR)是口服高效的第3代头孢菌素,具有较强的抗革兰阴性菌和革兰阳性菌的作用,组织分布广泛,血浆半衰期(T1/2)较长,对β-内酰胺酶稳定,耐受性良好,具有治疗剂量小、给药次数少、临床疗效确切等优点,在国外儿童多种感染性疾病的治疗指南中被推荐应用。在世界细菌耐药严峻的形势下,探讨合理应用CPDX-PR口服制剂,有重要的临床意义。现综述CPDX-PR的药理特性和治疗儿科常见感染性疾病的研究进展,以促进我国加强其临床合理应用的研究。

Cefpodoxime proxetil(CPDX-PR)is the third generation cephalosporin with high oral efficiency.It has strong anti-gram negative bacteria and-gram positive bacteria effects,with wide tissue distribution,long plasma half-time(T1/2),stable to lactamase,good tolerance,small therapeutic dose,few times of administration,definite cli-nical efficacy and other advantages.It is recommended for application in the treatment guidelines of foreign children with various infectious diseases.It is of great clinical significance to discuss the rational application of CPDX-PR oral preparation under the condition of severe bacterial drug resistance.This article reviews the pharmacological characteristics of CPDX-PR and the research progress in the treatment of common infectious diseases in pediatrics,so as to promote the research on the rational clinical application of CPDX-PR in China.