环磷腺苷葡胺与琥珀酸美托洛尔联合胺碘酮治疗急性心肌梗死心律失常的疗效

Efficacy of meglumine adenosine cyclic phosphate and metoprolol succinate combined with amiodarone in the treatment of arrhythmia in acute myocardial infarction

目的探讨对急性心肌梗死合并心律失常患者给予环磷腺苷葡胺、琥珀酸美托洛尔+胺碘酮进行联合治疗的临床效果。方法选取本院于2017年9月至2018年9月接受治疗的92例急性心肌梗死患者,根据所采取的不同治疗方法分为单一组和联合组,各46例。单一组患者单纯接受胺碘酮治疗,联合组患者在单一组的基础上,接受注射用环磷腺苷葡胺以及琥珀酸美托洛尔进行联合治疗,收集并统计两组患者的临床信息,并且进行心功能指标、治疗效果以及不良反应发生率的对比。结果两组患者治疗前的心功能指标比较差异无统计学意义,治疗后联合组左室舒张末期内径(LVEDD)、左心射血分数(LVEF)以及心输出量(CO)等心功能指标均优于单一组,联合组的治疗有效率43例(93.48%)显著高于单一组35例(76.09%),联合组的不良反应发生率3例(6.52%)显著低于单一组10例(21.74%),两组比较差异具有统计学意义(P<0.05)。结论对急性心肌梗死合并心律失常患者给予注射用环磷酰胺葡胺和琥珀酸美托洛尔+胺碘酮进行联合治疗,能够有效改善患者的心功能,治疗效果十分显著。

Objective To investigate the clinical effects of combination therapy with cyclophosphamide, metoprolol succinate and amiodarone in patients with acute myocardial infarction and arrhythmia. Methods Atotal of 92 patients with acute myocardial infarction who were treated in our hospital from September 2017 to September 2018 were divided into single group and combined group according to different treatment methods, with 46 cases in each group. A single group of patients received amiodarone alone, and the combination group received a combination of cyclophosphamide and metoprolol succinate on a single group, collecting and counting the two groups of patients. Clinical information, and a comparison of cardiac function indicators, treatment effects, and incidence of adverse reactions. Results There was no significant difference in the cardiac function between the two groups before treatment.After treatment, the left ventricular end-diastolic diameter (LVEDD), left ventricular ejection fraction (LVEF) and cardiac output (CO) of the combined group were all better than those of the single group.The effective rate of 43 patients in the combined group (93.48%) was significantly higher than that of 35 patients in the single group (76.09%), and the incidence of adverse reactions in 3 patients in the combined group (6.52%) was significantly lower than that in 10 patients in the single group (21.74%). Compared with the single group, the effective rate of treatment in the combined group was significantly higher in 43 cases (93.48%) than in the single group (36.09%), and the incidence of adverse reactions in the combined group was significantly lower in 3 cases (6.52%) than in the single group 10 cases (21.74%), the difference between the two groups was statistically significant (P<0.05). Conclusion The combination of cyclophosphamide glucamide for injection and metoprolol succinate + amiodarone for patients with acute myocardial infarction and arrhythmia can effectively improve the heart function of patients, and the treatment effect is very significant.