甲基强的松龙治疗急性期多发性硬化症的临床效果

Clinical effect of methylprednisolone in the treatment of acute multiple sclerosis

目的探究甲基强的松龙治疗急性期多发性硬化症的临床效果。方法选取2017年9月至2018年10月患有多发性硬化症疾病研究对象88例,按照随机数字的方式将患者分为观察组和对照组,各44例。对照组主要应用地塞米松药物进行治疗,观察组主要应用甲基强的松龙药物进行治疗,比较分析两组患者在治疗效果、EDSS评分、住院时间和住院费用以及随访1年后的复发情况。结果观察者的治疗效果为95.45%,对照组的治疗效果为70.45%,观察组效果高于对照组(P<0.05)。观察组的治疗后EDSS、住院时间、住院费用优于对照组,观察组随访1年后的复发人数为5例,复发率为11.36%,复发间隔月为(11.4±1.5)个月,对照组复发人数为18例,复发率为40.91%,复发间隔月为(5.2±1.3)个月,观察组优于对照组,差异具有统计学意义(P<0.05)。结论甲基强的松龙治疗急性期多发性硬化症的临床效果显著,能够为今后的相关研究提供借鉴。

Objective To investigate the clinical effect of methylprednisolone in the treatment of acute multiple sclerosis. Methods 88 patients with multiple sclerosis disease were selected from September 2017 to October 2018. They were divided into observation group and control group according to random numbers method, with 44 cases in each group. The control group was mainly treated with dexamethasone. The main group was treated with methylprednisolone. Comparative analysis of treatment outcomes, EDSS scores, length of hospital stay and hospitalization costs, and recurrence after 1 year of follow-up. Results The therapeutic effect of the observer was 95.45%, and the therapeutic effect of the control group was 70.45%. The effect of the observation group was much higher than that of the control group. In addition, the post-treatment EDSS, hospitalization time, and hospitalization expenses of the observation group were much better than those of the control group. The number of relapses after one year of follow-up was 5 cases, the recurrence rate was 11.36%, and the recurrence interval was (11.4±1.5) months. The number of patients with recurrence in the control group was 18 cases, the recurrence rate was 40.91%, and the recurrence interval was (5.2±1.3) months. The observation group was su- perior to the control group, and the difference was significant (P<0.05). Conclusion The clinical effect of methylprednisolone in the treatment of acute multiple sclerosis is significant, and it can be used as a reference for future research.