闭合式无线纳米孔电极的一步法制备及单颗粒检测研究

One-step Method for Fabrication of Closed Wireless Nanopore Electrode and Its Application on Single Nanoparticle Detection

以锥形石英固体纳米孔为模板,通过化学法制备具有金纳米结构的纳米孔尖端,从而实现一步法简单、快速地制备直径为30 nm的闭合式无线纳米孔电极(CWNE);探讨了制备过程中反应物浓度对制备过程的影响,制备成功率高达85.7%,RMS噪音低至4.2 pA.以金纳米颗粒碰撞电极实验为电化学测量模型,获得了单个颗粒与纳米孔电极相互作用的信号,验证了闭合式无线纳米孔电极对微秒级电信号的皮安级电流分辨能力,为进一步探索纳米界面上的电子传递过程提供了稳定的测量界面.

We developed a one-step method based on the chemical reduction of HAuCl4 to fabricate a closed wireless nanoelectrode( CWNE) which provides a high reproducibility in both electrode size and signal-to-noise ratio. By studing the reactant concentration,the successful ratio for fabricating 30 nm CWNE is increased to85. 7% and RMS noise value is decreased to 4. 2 pA. Furthermore,the CWNE was applied in the single nanoparticle collision detection which shows a high current resolution at picoampere level and a high temporal resolution at microsecond level. Therefore,the CWNE could be further benefit to achieve the accurate nano-electrochemical measurements.