万古霉素不良反应文献分析

Literature Analysis of Adverse Reaction of Vancomycin

目的:对万古霉素不良反应的国内文献进行检索、分类、统计分析,探讨国人应用万古霉素出现不良反应的特征,为万古霉素更安全,更合理的临床应用提供参考。方法:通过检索2008年1月—2017年12月中国期刊网全文和学位论文数据库(CNKI)、万方医学网、维普中文科技期刊全文数据库中有关万古霉素不良反应的文献资料。将文献分为个案或典型病例报告、同期对照临床研究或观察报告两类,进行归类整理,计算万古霉素不良反应的发生率、发生类型、发生时间以及各类型构成比。结果:最终纳入36篇文献共报道112例不良反应,不良反应类型主要为红人综合征、肾功能损害等,以速发型为主。结论:万古霉素不良反应发生较常见,临床应用应注意其不良反应,及时进行监护。

Objective To explore the characteristics of the adverse reactions of vancomycin to provide reference for the safe and reasonable clinical use.Methods To retrieve full text database of vancomycin adverse reactions in CNKI,Wanfang Network,VIP Chinese Science Technology Periodicals from January 2008 to December 2017.The literature was divided into case and typical cases report,concurrent control clinical study or observation reports,to calculate the incidence rate of adverse reactions,occurrence time and various types ratio.Results The typical reports of 112 cases of adverse reactions were observed,and the main type was Reds syndrome,renal dysfunction,etc,mainly to the rapid onset.Conclusion The adverse reactions of vancomycin are more common,and its adverse reactions should be paid attention to and monitored for ensuring its safety in use.