4种炎症因子在牙周炎与冠心病相关性中的作用

The role of four inflammatory factors in the relationship between periodontitis and coronary heart disease

目的:探讨4种炎症因子IL-1β、IL-6、TNF-α、MCP-1在牙周炎与冠心病(CHD)相关性中的可能角色,进一步探索牙周炎和CHD的相关机制。方法:选取2015年7月至2016年5月就诊于温州市中医院口腔科及温州市人民医院心内科的129例研究对象,其中健康者39名,单纯中重度牙周炎患者35例,单纯CHD患者31例,CHD伴中重度牙周炎患者24例,采用定制的ProcartaPlex多因子ELISA试剂盒检测每位受检者的血清IL-1β、IL-6、TNF-α、MCP-1含量。结果:经协方差分析排除危险因素BMI和血压的作用后,各组血清IL-1β、IL-6、TNF-α、MCP-1的差异有统计学意义(P<0.05),CHD伴中重度牙周炎组最高。除MCP-1以外,中重度牙周炎组和CHD组血清IL-1β、IL-6、TNF-α水平均高于健康组。结论:中重度牙周炎患者升高的血清IL-1β、IL-6、TNF-α水平,可能促进CHD的发生发展。

Objective: To study the possible role of inflammatory factors(including IL-1β, IL-6, TNF-α, MCP-1) in the association between periodontal diseases and CHD. Methods: A total of 129 cases were selected from the Department of Stomatology of Wenzhou Chinese Medicine Hospital and the Cardiovascular Department of Wenzhou People’s Hospital from July 2015 to May 2016, including 39 healthy swarm(HC group), 35 cases of chronic moderate and severe forms of periodontitis(PD group), 31 cases of coronary heart disease alone(CHD group) and 24 cases of coronary artery disease along with periodontitis(PD+CHD group). The IL-1β, IL-6, TNF-α and MCP-1 in the serum of each recipient were detected by ELISA method. Results: There was statistical difference in IL-1β, IL-6, TNF-α, MCP-1 among enrolled groups(P<0.05).The levels of IL-1β, IL-6, TNF-α and MCP-1 were highest in PD+CHD group, while the levels of IL-1β, IL-6 and TNF-α in PD group and CHD group were higher than those in HC group. Conclusion: The elevated serum levels of IL-1β, IL-6 and TNF-α in patients with moderate to severe periodontitis may promote the progression of CHD.