特利加压素在肝硬化食管胃静脉曲张出血中的应用

Application of terlipressin in the treatment of esophagogastric variceal bleeding in liver cirrhosis

食管胃静脉曲张破裂出血(EVB)是继发于肝硬化门静脉高压的一种常见致死性的并发症。特利加压素可以收缩内脏血管、降低门静脉压力、增加肾脏灌注,主要用于治疗EVB。总结了特利加压素治疗肝硬化EVB的作用机制、疗效等,认为特利加压素可有效控制EVB,且在条件允许的情况下,应优先选择特利加压素联合内镜下曲张静脉套扎术治疗EVB。

Esophagogastric variceal bleeding (EVB) is a common fatal complication secondary to cirrhotic portal hypertension.Terlipressin can shrink visceral blood vessels,reduce portal pressure,and increase renal perfusion and is mainly used in the treatment of EVB.This article summarizes the mechanism of action and clinical effect of terlipressin in the treatment of EVB in liver cirrhosis and points out that if conditions permit,terlipressin combined with endoscopic variceal ligation should be the preferred treatment method for EVB.