非酒精性脂肪性肝病与膳食炎症指数的关系及现实意义

Association between nonalcoholic fatty liver disease and dietary inflammation index and its practical significance

近年来,非酒精性脂肪性肝病(NAFLD)的发病率不断攀升,且逐渐呈低龄化发展态势,包括不良饮食选择在内的不健康的生活方式是其主要诱因之一。但是,目前NAFLD的治疗方案尚不确切,以体质量减轻为目标的生活方式干预依然是治疗NAFLD最成熟的方法。研究表明,慢性炎症反应贯穿着NAFLD发生发展的全过程,而饮食在炎症级联的发展和调节中发挥着重要作用。膳食炎症指数是用于评估个人饮食结构中的炎症潜能的有效工具,自开发以来不断完善,现已广泛应用于多种疾病的临床研究中。探讨了NAFLD与膳食炎症指数的相关性,以期从饮食结构上对NAFLD进行一级预防,降低NAFLD的发病率。

In recent years,the incidence rate of nonalcoholic fatty liver disease (NAFLD) keeps increasing,and the age of onset gradually becomes younger.Unhealthy lifestyle,including bad dietary choices,is one of the major causes of NAFLD.However,there are still no clear treatment regimens for NAFLD,and lifestyle intervention with the aim of weight loss is still the most mature method for the treatment of NAFLD.Studies have shown that chronic inflammatory response runs through the whole process of the development and progression of NAFLD,and diet plays an important role in the development and regulation of inflammatory cascade.Dietary inflammation index (DII) is an effective tool for assessing inflammatory potential in individual dietary structure,and since its development,it has been continuously improved and is now widely used in the clinical research on many diseases.This article discusses the association between NAFLD and DII,in order to achieve primary prevention of NAFLD from dietary structure and reduce the incidence rate of NAFLD.