我院48例难治性精神分裂症病人残留症状及相关影响因素的调查分析

Investigation and Analysis of the Residual Symptoms and Related Factors in 48 Patients with Refractory Schizophrenia in Our Hospital

目的:调查探究某院48例难治性精神分裂症患者残留症状及相关影响因素,为临床提供指导。方法:抽取于2013年10月~2016年10月来某院就医的48例难治性精神分裂症患者(实验组)及同期来某院治疗的70例非难治性精神分裂症患者(对照组)作为此次实验的目标对象,对48例难治性精神分裂症患者及70例非难治性精神分裂症患者的临床资料进行回顾性分析,分析难治性精神分裂症患者的残留症状及相关影响因素。结果:实验组患者残留症状的结果显著多于对照组患者,且实验组及对照组患者组间的病程、性别比例、自行停药史、家族史、系统治疗、服药情况及强迫症结果存在显著差异,P<0.05;强迫症与患者服用氯氮平成正相关。结论:病程过长、男性、自行停药、家族遗传、未系统治疗、服药种类可能是导致难治性精神分裂症的危险因素,且结果显示难治性精神分裂症患者出现残留症状的比例较高,所以,在治疗过程中,临床医师应结合患者的实际情况为其选择合适的治疗方案,避免病情进展为难治性精神分裂症。

Objective:To investigate the residual symptoms and related influencing factors in 48 patients with refractory schizophrenia in a hospital,and to provide guidance for clinical practice. Methods:48 patients with refractory schizophrenia treated in ahospitd from October 2013 to October 2016(experimental group) and 70 cases of non-refractory schizophrenia(control group) treated in a hospital at the same time were selected as the target of this experiment. The clinical data of 48 patients with refractory schizophrenia and 70 patients with non-refractory schizophrenia were analyzed retrospectively,and the residual symptoms and related factors of the patients with refractory schizophrenia were analyzed. Results:The results of residual symptoms in the experimental group were significantly higher than those in the control group. There were significant differences in the course of disease,sex ratio,self-withdrawal history,family history,systemic treatment,drug taking and obsessive-compulsive disorder between the patients in the experimental group and the control group(P<0.05). There was a positive correlation between obsessive-compulsive disorder and clozapine taking in patients. Conclusion:The long course of the disease,the male,the self-stop drug,the family heredity,the non-system treatment,and the type of the medicine may be the risk factors leading to the refractory schizophrenia,and the result shows that the proportion of the residual symptoms in the patients with the refractory schizophrenia is high. Therefore,in the course of treatment,clinicians should choose the appropriate treatment scheme according to the actual conditions of the patients,so as to avoid the disease progression to a refractory schizophrenia.