左乙拉西坦治疗小儿癫痫的疗效和安全性评价

Efficacy and Safety Evaluation of Levetiracetam in Children with Epilepsy

目的:根据小儿癫痫患者的病情特征,采用左乙拉西坦进行治疗,分析其疗效与安全性。方法:将某院治疗的小儿癫痫患者中随机抽取32例,按照其住院号的先后顺序将其分为研究组和参照组。研究组患者服用左乙拉西坦进行治疗,参照组采用卡马西平缓释胶囊进行治疗,治疗结束后将两组患者的癫痫发作频率、临床总有效率、不良反应情况等进行分析比较。结果:与参照组比较,研究组患者的癫痫发作频率、癫痫发作持续时间明显较短,临床总有效率(93.8%)明显较高,且不良反应率(18.8%)较低,差异具有统计学意义。结论:左乙拉西坦治疗小儿癫痫的治疗效果较好,且安全性高、无明显不良反应,在今后的临床实践中值得应用。

Objective:To analyze the efficacy and safety of levetiracetam according to the characteristics of pediatric epilepsy patients. Methods:Thirty-two patients with pediatric epilepsy treated in a hospital were randomly selected and divided into study group and reference group according to the order of their hospitalization. Patients in the study group were treated with levetiracetam,and the reference group was treated with carbamazepine sustained-release capsules. After the treatment,the seizure frequency,clinical total effective rate,and adverse reaction situation of the two groups were analyzed and compared. Results:Compared with the reference group,the seizure frequency and seizure duration of the study group were significantly shorter,the total clinical effective rate(93.8%) was significantly higher,and the adverse reaction rate(18.8%) was lower. The differences were statistically significant. Conclusion:Levetiracetam is effective in the treatment of children with epilepsy,and it has high safety and no obvious adverse reactions,which is worthy of application in future clinical practice.