盐酸利托君与阿托西班对大于35岁先兆早产妇女保胎效果、围生儿结局及不良反应发生率的影响分析

Effect of Ritodrine Hydrochlorideand Atosiban on Prevent Miscarriages Outcomes, Perinatal Outcomes and Incidence of Adverse Reactions in Puerpera with Threatened Preterm Labor Older Than 35 Years Old

目的:评价探究盐酸利托君与阿托西班对大于35岁先兆早产妇女保胎效果、围生儿结局及不良反应发生率的影响。方法:选取某院年龄>35岁的先兆早产妇女88例进行观察,按照随机掷硬币法分为对照组(盐酸利托君)和观察组(阿托西班),分析两组的药物治疗情况。结果:观察组的保胎成功率、围生儿结局情况与对照组相比无统计学意义(P>0.05);两组不良反应率相比,观察组的明显较少,并且观察组的呼吸频率和心率跳动指标比对照组更稳定,对比有统计学意义(P<0.05)。结论:临床针对高龄先兆早产妇女采用盐酸利托君与阿托西班对保胎均有一定的疗效,但实际用药中阿托西班的安全性更高,对胎儿产生的不利影响小,值得临床深究。

Objective:To evaluate the effects of ritodrine hydrochloride and atosiban on prevent miscarriages outcomes,perinatal outcomes and incidence of adverse reactions in puerpera with threatened preterm labor older than 35 years old. Methods:88 women with threatened preterm labor at the age of more than 35 years old enrolled in a hospital were observed. The patients were divided into the control group(ritodrine hydrochloride) and the observation group(atosiban) according to the random coin toss method. The drug treatment status of the two groups was analyzed. Results:There was no significant difference in the success rate of prevent miscarriages outcomes and perinatal between the observation group and the control group(P>0.05). The adverse reaction rate of the observation group was significantly less than that of the observation group. In addition,respiratory rate and heart rate in the observation group were more stable than those in the control group,P<0.05. Conclusion:In clinical,the use of ritodrine hydrochloride and atosiban in puerpera with threatened preterm labor has a certain effect on prevent miscarriages,but the actual safety of atosiban is higher,and the adverse effects on the fetus are small,which is worthy of clinical study.