CT及MRI在胃肠道间质瘤靶向治疗疗效评价中的应用

Computed tomography and magnetic resonance imaging in the evaluation of treatment response of targeted therapy for gastrointestinal stromal tumor

目的详细总结近年来CT及MRI在胃肠道间质瘤(gastrointestinal stromal tumor,GIST)靶向治疗疗效评价中的进展。方法对近年来关于GIST靶向治疗疗效评价的影像学相关的指南、共识、国际会议报道及临床研究的相关知识进行归纳和总结。结果GIST靶向治疗后影像表现与病理改变密切相关,可以出现坏死、囊变、出血等多种征象。CT检查是其疗效评价的首选成像方式。功能磁共振技术如扩散加权成像(diffusion weighted imaging,DWI)在GIST靶向治疗的疗效评价方面取得了一定进展。GIST靶向治疗的疗效评价标准主要使用RECIST1.1和Choi标准。结论影像学评价是GIST靶向治疗疗效评价的重要手段。

Objective This review has summarized in detail the advances in computed tomography (CT) and magnetic resonance imaging (MRI) imaging in evaluating the efficacy of targeted therapy for gastrointestinal stromal tumor (GIST). Methods To summarize the image-related guidelines, consensus, international conference reports, and relevant knowledge of clinical research on the evaluation of the efficacy of GIST targeted therapy in recent years. Results The CT and MRI manifestation after targeted treatment of GIST was closely related to pathological changes, including necrosis, cystic degeneration, and bleeding. CT was the preferred imaging method. Functional magnetic resonance imaging, such as diffusion weighted imaging (DWI), had made some progress. The main criteria for evaluating the efficacy of GIST targeted therapy were RECIST 1.1 and Choi criteria. Conclusion CT and MRI play an important role in evaluating the efficacy of targeted therapy for GIST.