血清高密度脂蛋白水平与双相情感障碍患者认知功能的相关性

The relationship between serum high density lipoprotein levels and cognitive function in patients with bipolar disorder

目的探讨双相情感障碍患者血清高密度脂蛋白(High density lipoprotein,HDL)水平与其认知功能的相关性。方法在苏州市广济医院住院部招募99例双相情感障碍患者,采用比色法检测血清HDL水平。应用重复性成套神经心理状态测验(repeatable battery for the assessment of neuropsychological status,RBANS)评估患者认知功能。使用相关分析和逐步多元回归分析研究血清高密度脂蛋白与认知功能的关系。结果患者血清HDL水平[(1.39±0.55)mmol/L]与RBANS量表总分[(68.92±12.48)分](r=0.238,P=0.034)和言语功能分值[(80.59±15.97)分](r=0.239,P=0.033)均呈正相关。逐步多元回归分析显示患者血清HDL水平是RBANS总分(β=4.791,t=2.151,P=0.035)和言语功能(β=7.363,t=2.247,P=0.027)的影响因素。结论血清HDL水平可能会影响双相情感障碍患者的认知功能,特别是言语功能。

Objective To explore the correlation between serum high density lipoprotein (HDL) levels and cognitive function in patients with bipolar disorder. Methods A total of 99 patients with bipolar disorder were enrolled from the inpatient of Suzhou Guangji Hospital.Serum HDL levels were measured by enzymatic colourimetry.Cognitive function was assessed by the repeatable battery for the assessment of neuropsychological status (RBANS). The relationship between serum high density lipoprotein and cognitive function was analyzed by correlation analysis and stepwise multiple regression analysis. Results Serum HDL levels ((1.39±0.55)mmol/L)were positively correlated with the RBANS total score (68.92±12.48)(r=0.238, P=0.034) and language score(80.59±15.97)(r=0.239, P=0.033) in patients with bipolar disorder.Stepwise multiple regression analysis showed that serum HDL level was the influencing factor of total score of RBANS(β=4.791, t=2.151, P=0.035)and speech function(β=7.363, t=2.247, P=0.027). Conclusion Serum HDL levels can influence cognitive function, especially speech function in patients with bipolar disorder.