帕金森病患者自主神经功能障碍的影响因素分析

Analysis of influencing factors of autonomic dysfunction in patients with Parkinson’s disease

目的:探究帕金森病患者自主神经功能障碍的影响因素。方法:回顾性分析2015年3月至2018年9月的125例帕金森病患者的临床资料,根据患者是否存在自主神经功能障碍将其分为观察组(55例)和对照组(70例),观察组存在自主神经功能障碍,对照组无自主神经功能障碍。比较两组患者的病程、Hoehn-Yahr(H-Y)分期(H-Y)、UPDRSⅢ评分,总结导致帕金森病患者发生自主神经功能障碍的影响因素。结果:单因素分析结果显示,两组病程、H-Y分期、UPDRSⅢ评分方面比较,差异有统计学意义(P<0.05);多因素Logistic线性回归分析结果显示,病程、H-Y分期、UPDRSⅢ评分是导致帕金森患者发生自主神经功能障碍的危险因素。结论:帕金森病患者因病程、H-Y分期、UPDRSⅢ评分因素的影响,易发生自主神经功能障碍。

Objective:To explore influencing factors of autonomic dysfunction in patients with Parkinson’s disease.Methods:The clinical data of 125 patients with Parkinson’s disease in our hospital from March 2015 to September 2018 were retrospectively analyzed.Depending on autonomic dysfunction or not, these patients were divided into observation group (55 cases with autonomic dysfunction) and control group (70 cases without autonomic dysfunction).The course of disease, Hoehn-Yahr staging, and UPDRS III scores were compared between the two groups.Then, the influencing factors of autonomic dysfunction were summarized.Results:The univariate analysis showed that there were significant differences in the course of disease, Hoehn-Yahr staging and UPDRS Ⅲ score between the observation group and the control group (P<0.05).The multivariate logistic regression showed that the course of disease, Hoehn-Yahr staging, U-DRS Ⅲ score were the risk factors for autonomic dysfunction in the patients with Parkinson’s disease.Conclusions:The patients with Parkinson’s disease are prone to autonomic dysfunction due to the influencing factors including the course of disease, Hoehn-Yahr staging, and UPDRS Ⅲ score.