HPV与液基细胞学联合检测对宫颈癌的筛查价值

Screening value of combined detection of HPV and liquid-based cytology for cervical cancer

目的:探讨人乳头瘤病毒(HPV)联合液基细胞学检测(TCT)在宫颈癌筛查中的应用价值。方法:采用回顾性分析方法,选择2017年1月至2018年6月本院具有宫颈活体组织检查结果的443例宫颈癌筛查患者作为研究对象,均经HPV检测及液基细胞学检测,比较分析单独HPV检测、单独液基细胞学检测及二者联合检测对宫颈癌的诊断效能。结果:443例患者中,HPV筛查阳性检出率为44.02%,随组织病理学诊断级别的升高,HPV感染阳性率显著增高(P<0.05),组织病理学检测结果≥CINI为阳性者87例,阳性检出率为19.64%,TCT筛查结果≥LSIL为阳性者69例,阳性检出率为15.58%。HPV与TCT联合筛查的灵敏度、符合率、阳性检出率、阴性检出率均显著高于任何一项单独检测,差异均具有统计学意义(P<0.05)。结论:联合HPV与液基细胞学检测能够有效提高宫颈癌患者的筛查率,临床诊断意义重大。

Objective:To explore the value of human papillomavirus(HPV)combined with thinprep cytologic test(TCT)in screening cervical cancer.Methods:Using retrospective analysis,443 patients with cervical biopsy results from January 2017 to June 2018 were selected as subjects,all tested by HPV and liquid-based cytology.HPV,liquid-based cytology test and the combined detection of the two for the diagnosis of cervical cancer.Results:Among 443 patients,the positive rate of HPV screening was 44.02%.With the increase of histopathological diagnosis,the positive rate of HPV infection was significantly increased(P<0.05).Histopathological results≥CIN I was positive in 87 cases,the positive detection rate was 19.64%,and the TCT screening result was≥LSIL was positive in 69 cases,and the positive detection rate was 15.58%.The sensitivity,coincidence rate,positive detection rate and negative detection rate of HPV and TCT combined screening were significantly higher than any single test,and the difference was statistically significant(P<0.05).Conclusion:The combination of HPV and liquid-based cytology can effectively improve the screening rate of cervical cancer patients.