摘要
[Objectives] This study was conducted to observe the protective effect of Pratia extract on acute liver injury in mice.[Methods] Mice were randomly divided into 6 groups according to body weight,10 in each group: normal control group,ethanol-induced/CCl4 liver injury model,low-dose,middle-dose and high-dose Pratia extract groups,and bifendatatum group.Except the blank group,other groups were given 50% ethanol intragastrically at a dose of 12 ml/kg to cause acute alcoholic liver injury,or intraperitoneally injected with 10% CCl4 soybean oil solution to cause acute CCl4 liver injury.The serum ALT and AST activity were measured as well as liver SOD and MDA concentrations.[Results] Pratia extract effectively reduced serum ALT and AST,decreased MDA content and increased liver tissue SOD activity.[Conclusions] Pratia extract has certain protective effect on acute liver injury.
[Objectives] This study was conducted to observe the protective effect of Pratia extract on acute liver injury in mice. [Methods] Mice were randomly divided into 6 groups according to body weight, 10 in each group: normal control group, ethanol-induced/CCl4 liver injury model, low-dose, middle-dose and high-dose Pratia extract groups, and bifendatatum group. Except the blank group, other groups were given 50% ethanol intragastrically at a dose of 12 ml/kg to cause acute alcoholic liver injury, or intraperitoneally injected with 10% CCl4 soybean oil solution to cause acute CCl4 liver injury. The serum ALT and AST activity were measured as well as liver SOD and MDA concentrations. [Results] Pratia extract effectively reduced serum ALT and AST, decreased MDA content and increased liver tissue SOD activity. [Conclusions] Pratia extract has certain protective effect on acute liver injury.
基金
Supported by Youth Fund of Guangxi Natural Science Foundation(2010GXNSFB013075)
Nanning Traditional Chinese Medicine Quality Control Engineering Research Center Construction Project(20181020-2)
