无症状脑梗死患者发生抑郁的危险因素分析

Risk factors of depression in patients with silent cerebral infarction

目的 探讨无症状脑梗死患者发生抑郁的危险因素。方法 选取2016年8月至2018年5月入住海口市人民医院神经内科的无症状脑梗死患者作为研究对象,根据有无发生抑郁的结果分为抑郁组和无抑郁组,记录各组患者的临床资料。结果 抑郁组和无抑郁组在认知功能、额叶部位梗死、同型半胱氨酸(Hcy)、家族史等方面比较,差异有统计学意义(P<0.05)。多因素Logistic回归分析显示认知功能障碍、额叶部位梗死、高同型半胱氨酸血症(Hhcy)是无症状脑梗死患者发生抑郁的高危因素(P<0.05)。结论 认知功能障碍、额叶部位梗死及Hhcy是无症状脑梗死患者发生抑郁的独立危险因素。

Objective To explore the risk factors of depressive symptoms in patients with silent cerebral infarction. Method Patients with silent cerebral infarction admitted to the department of Neurology of Haikou People’s Hospital from August 2016 to May 2018 were selected as the research object, and divided into depression group and non-depression group according to the results of depressive symptoms, and the clinical data of each group were recorded. Results There were significant differences in cognitive function, frontal infarction, homocysteine (Hcy) and family history between depression group and non-depression group( P < 0.05 ). Multivariate Logistic regression analysis showed that cognitive dysfunction, frontal lobe infarction and hyperhomocysteinemia(Hhcy) were high risk factors for depression in patients with silent cerebral infarction(P < 0.05). Conclusion Cognitive dysfunction, frontal lobe infarction and Hhcy are independent risk factors for depression in patients with silent cerebral infarction .