冠心病患者血浆富含半胱氨酸蛋白61表达水平及临床意义

Expression level and clinical significance of plasma cysteine-rich protein 61 in patients with coronary heart disease

目的探讨冠心病患者血浆富含半胱氨酸蛋白61(CYR61)的表达水平及其临床意义。方法纳入108例冠心病患者(冠心病组,其中心绞痛患者63例及急性心肌梗死患者45例),另选取冠脉造影阴性患者30例(对照组)。比较冠心病组和对照组间及不同类型冠心病患者的一般临床资料及血浆CYR61水平的差异,采用Logistic回归模型分析冠心病发生的危险因素,并采用受试者工作特征(ROC)曲线评价血浆CYR61水平诊断急性心肌梗死的效能。结果冠心病组血浆CYR61水平高于对照组,急性心肌梗死患者血浆CYR61水平高于心绞痛患者(均P<0.05)。血浆CYR61水平升高是冠心病发生的危险因素(P<0.05)。CYR61、肌钙蛋白诊断急性心肌梗死的ROC曲线下面积分别为0.869、0.787,差异无统计学意义(P>0.05)。结论冠心病患者血浆CYR61水平升高,其中急性心肌梗死患者的血浆CYR61水平较心绞痛患者更高。CYR61与冠心病的发生密切相关,并对急性心肌梗死具有一定的诊断效能。

Objective To explore the expression level and clinical significance of plasma cysteine-rich protein 61(CYR61) in patients with coronary heart disease(CHD).Methods A total of 108 CHD patients were enrolled as CHD group,including 63 patients with angina pectoris and 45 patients with acute myocardial infarction,and another 30 patients with negative coronary angiography were enrolled as control group.The general clinical data and plasma CYR61 level were compared between the CHD group and the control group,or between patients with CHD of different types,Logistic regression model was applied to risk factors analysis of developing CHD,and receiver operating characteristic(ROC) curve was used to assess the diagnostic efficiency of plasma CYR61 level for acute myocardial infarction.Results The plasma level of CYR61 in the CHD group was higher than that in the control group,the plasma CYR61 level of patients with acute myocardial infarction was higher than that of patients with angina pectoris (all P <0.05).Elevated plasma CYR61 level was the risk factor of developing CHD( P <0.05).For diagnosing acute myocardial infarction,the areas under ROC curve of CYR61 and troponin were 0.869 and 0.787,respectively,exhibiting no statistically significant difference( P >0.05).Conclusion Plasma CYR61 level increases in CHD patients,and is higher in patients with acute myocardial infarction compared with the level in patients with angina pectoris.CYR61 is closely related to the occurrence of CHD,and obtains a certain efficiency for diagnosing acute myocardial infarction.