含铋剂四联疗法治疗幽门螺旋杆菌阳性胃溃疡的临床效果

Clinical efficacy of bismuth-containing quadruple therapy for Helicobacter pylori-positive gastric ulcer

目的探讨含铋剂四联疗法治疗幽门螺旋杆菌(Hp)阳性胃溃疡的临床效果。方法回顾性分析120例Hp阳性胃溃疡患者的临床资料。对照组(n=60)给予兰索拉唑肠溶片、四环素、甲硝唑三联疗法,观察组(n=60)在三联疗法基础上,加用胶体果胶铋胶囊治疗。两组患者均连续治疗14d。比较两组停药6周后的胃溃疡疗效、Hp根除率以及随访1年期间溃疡复发率、Hp复发率。结果观察组患者Hp根除率及胃溃疡疗效均高于对照组,溃疡复发率及Hp复发率均低于对照组(均P<0.05)。结论在三联疗法的基础上,加用胶体果胶铋治疗Hp阳性胃溃疡,可以提高疗效,降低胃溃疡复发率。

Objective To investigate the clinical efficacy of bismuth-containing quadruple therapy for Helicobacter pylori (Hp)-positive gastric ulcer.Methods The clinical data of 120 patients with Hp-positive gastric ulcer were analyzed retrospectively.The control group( n =60) was given triple therapy of Lansoprazole Enteric-Coated Tablets,tetracycline and metronidazole,and the observation group( n =60) received additional Colloidal Bismuth Pectin Capsules on the basis of triple therapy.Patients in the two groups were treated for 14 consecutive days.The efficacy for gastric ulcer and Hp eradication rate 6 weeks after medication discontinuation as well as the rates of ulcer and Hp recurrence during 1-year follow-up period were compared between the two groups.Results The observation group had higher Hp eradication rate,higher efficacy for gastric ulcer,lower rates of ulcer and Hp recurrence than the control group(all P <0.05).Conclusion On the basis of triple therapy,the use of additional Colloidal Bismuth Pectin Capsules can improve efficacy,and reduce the recurrence rate of gastric ulcer in the treatment of Hp-positive gastric ulcer.