穴位贴敷联合西药分期防治肺癌化疗后消化道不良反应

Parallel Control Study of Acupoint Application combined with Western Medicine in Staged Prevention and Treatment of Gastrointestinal Adverse Reactions after Lung Cancer Chemotherapy

[目的]观察穴位贴敷联合西药分期防治肺癌化疗后消化道不良反应疗效。[方法]将52例住院患者按治疗方法分两组。对照组26例化疗前,胃复安,2.0 g/次,口服,3次/d;托烷司琼,2.0 g/次,口服,3次/d;地塞米松,2 mg/次,3次/d,静滴。治疗组26例穴位贴敷,在化疗前30 min指导患者取仰卧位,取天突、神阙、足三里、涌泉、中脘、内关等,稍稍用力按压,直至患者感觉到酸胀和疼痛,使用浓度为75%的酒精片擦洗贴敷部位,干燥后,将穴位贴逐个贴好,叮嘱患者家属每日在早中晚进行按压,且每天更换,直至化疗结束。另外吴茱萸加醋调制至1 cm左右的球状,在双侧涌泉穴用胶布固定好;西药治疗同对照组。连续治疗7 d为1疗程。观测临床表现、不良反应评分。连续治疗3疗程,判定疗效。[结果]治疗组显效8例,有效14例,无效4例,总有效率84.62%;对照组显效3例,有效11例,无效12例,总有效率53.85%;治疗组疗效优于对照组(P<0.05)。不良反应评分治疗组低于对照组(P<0.01)。[结论]穴位贴敷联合西药分期防治肺癌化疗后消化道不良反应,疗效满意,无严重不良反应,值得推广。

[Objective]To observe the efficacy of acupoint application combined with western medicine on preventing and treating gastrointestinal adverse reactions after chemotherapy for lung cancer.[Methods]A total of 52 hospitalized patients were divided into two groups according to the treatment method using multiple parallel control methods.Control group’s 26 cases before chemotherapy were given metoclopramide with the dose of 2.0 g/time orally 3 times/d and tropisetron with the dose of 2.0 g/time orally 3 times/d and dexamethasone with the dose of 2 mg/time by intravenous drip 3 times/d to prevent adverse reactions in the digestive tract.In the treatment group,acupoints application was applied.The patient was instructed to take the supine position 30 minutes before chemotherapy.Tiantu(RN22),Shenque(RN8),Zusanli(ST36),Yongquan(KI1),Zhongwan(RN12)and Neiguan(PC6)were pressed hard until the patients felt sore and pain.After scrubbing the application site with 75%alcohol and drying,acupoint application was applied.The family members pressed daily in the morning and evening,and replaced every day until the chemotherapy was over.In addition,Wusong vinegar was conditioned to a spherical shape of about 1 cm,and it was fixed with glue on both sides of Yongquan(KI1).The western medicine was the same as that of the control group.Continuous treatment for 7 days was a course of treatment.We observed clinical manifestations and adverse reaction scores.After continuous treatment for 3 courses,the efficacy was studied.[Results]In the treatment group,8 cases were markedly effective,14 cases effective,4 cases ineffective,and the total effective rate was 84.62%.The control group was effective in 3 cases,effective in 11 cases,ineffective in 12 cases,and the total effective rate was 53.85%.The therapeutic effect was better than that of the control group(P<0.05).The adverse reaction scores in the treatment group were lower than those in the control group(P<0.01).[Conclusion]Acupoint application combined with Western medicine to prevent and treat gastrointestinal adverse reactions after chemotherapy for lung cancer has satisfactory results,with no serious adverse reactions,worthy of promotion.