荨麻疹与特应性皮炎患者血清过敏原抗体检测分析

Detection and analysis of serum allergen in patients with urticaria and atopic dermatitis

目的探讨荨麻疹与特应性皮炎患者血清过敏原总IgE抗体及特异性IgE(sIgE)抗体含量的差异。方法选择2015年1月-2017年12月天津市北辰医院接诊的变态反应性皮肤病患者140例为研究对象,特应性皮炎组56例,荨麻疹组84例,分别采集2组患者静脉血,检测血清过敏原总IgE抗体和slgE抗体含量。结果荨麻疹组血清总IgE阳性率为82.14%,高于特应性皮炎组的55.36%,差异有统计学意义(P<0.05);荨麻疹组2种血清过敏原SIgE阳性率和slgE总阳性率低于特应性皮炎组,差异有统计学意义(P<0.05);荨麻疹组3种及以上slgE阳性率和1种slgE阳率与特应性皮炎组比较,差异无统计学意义(P>0.05)。结论荨麻疹与特应性皮炎血清过敏原总IgE阳性率检出不同,荨麻疹检出率最高,多数患者存在多种过敏原交叉反应。

Objective To investigate the difference of serum allergen total IgE antibody and specific immunoglobulin E ( sIgE) antibody contents in patients with urticaria and atopic dermatitis and their allergens. Methods 140 patients with allergic dermatosis in our hospital from January 2015 to December 2017 were selected, including atopic dermatitis group (56 cases) and urticaria group (84 cases). The venous blood of two groups was collected, and the serum allergen total IgE antibody and sIgE antibody contents were deteeted. Results The positive rale of serum total IgE in urticaria group was 82. 14%,which was higher than that (55. 36%) in atopic dermatitis, with the difference statistically significant (P<0. 05). The sIgE positive rate of 2 serum allergens and total positive rate of sIgE in urticaria group were lower than those in atopic dermatitis, with the difference statistically significant (P <0.05). There was no statistical significance on the difference in the sIgE positive rate of 3 allergens or above and in the positive' rate of 1 allergen between urticaria group and atopic dermatitis (P>0.05). Conclusion The positive rate of serum allergen total IgE in urticaria and atopic dermatitis are different, and the detection rate in urticaria was the highest. Most of patients have cross reaction of multiple allergens.