丙戊酸钠联合左乙拉西坦治疗脑卒中后癫痫效果及对患者血NSE、IL-6和TNF-α水平的影响

Effects of Sodium Valproate Combined with Levetiracetam on Post-stroke Epilepsy and its Influence on Levels of Blood NSE, IL-6 and TNF-α

目的探讨丙戊酸钠联合左乙拉西坦治疗脑卒中后癫痫效果及对患者血NSE、IL-6和TNF-α水平的影响。方法选取2015年3月至2017年9月在我院进行治疗的脑卒中后癫痫患者162例,采用随机数表法分为观察组(n=81)和对照组(n=81),对照组采用丙戊酸钠治疗,观察组在对照组基础上联合左乙拉西坦治疗,观察两组疗效、神经递质NSE及炎症反应。结果观察组治疗有效率96.30%较对照组83.95%高,差异比较有统计学意义(P<0.05);治疗后,两组血NSE、TNF-α、IL-6水平均较治疗前有所降低,且观察组血NSE、TNF-α、IL-6水平均低于对照组,比较有统计学差异(P<0.05);观察组不良反应发生率3.70%低于对照组7.41%,但比较无统计学差异(P>0.05)。结论丙戊酸钠联合左乙拉西坦治疗脑卒中后癫痫效果较好,能有效改善患者神经功能,降低神经损伤,降低炎症反应,安全有效,值得在临床推广。

Objective To explore the effects of sodium valproate combined with levetiracetam on post-stroke epilepsy and its influence on levels of blood NSE,IL-6 and TNF-α.Methods A total of 162 patients with post-stroke epilepsy who were treated in our hospital from March 2015 to September 2017 were selected and divided into observation group(n=81)and control group(n=81)according to the random number table method.Control group was treated with sodium valproate,and observation group was combined with levetiracetam on the basis of control group.The efficacy,neurotransmitter NSE and inflammatory response were observed in the two groups.Results The effective rate of treatment in observation group was higher than that in control group(96.30%vs 83.95%)(P<0.05).After treatment,the levels of blood NSE,TNF-αand IL-6 in the two groups were lower than those before treatment,and the levels of blood NSE,TNF-αand IL-6 in observation group were lower than those in control group(P<0.05).The incidence rate of adverse reactions in observation group was lower than that in control group(3.70%vs 7.41%)(P>0.05).Conclusion Sodium valproate combined with levetiracetam is effective in treating post-stroke epilepsy.And it can effectively improve neurological function,reduce nerve damage and reduce inflammatory response.It is safe and effective and worthy of clinical promotion.