急性冠脉综合征患者N-proBNP、hs-CRP水平变化及其相关性分析

Changes of N-proBNP and hs-CRP Levels in Patients with Acute Coronary Syndrome and Their Correlation Analysis

目的观察急性冠脉综合征(ACS)患者N末端前体B型利钠肽(N-proBNP)、超敏C反应蛋白(hs-CRP)水平变化,并分析其相关性。方法选取我院收治的22例稳定性心绞痛(SAP)患者纳入SAP组与58例ACS患者,根据ACS病情差异分为急性心肌梗死(AMI)组、不稳定性心绞痛(UA)组,并取同期80例健康体检者纳入对照组,比较4组血清N-proBNP、hs-CRP水平,并分析N-proBNP与hs-CRP相关性。结果4组血清N-proBNP、hs-CRP水平为:AMI组>UA组>SAP组>对照组,比较有统计学意义(P<0.05);相关性分析显示,ACS患者血清N-proBNP水平与hs-CRP水平呈正相关(r=0.817,P<0.05)。结论ACS患者血清N-proBNP、hs-CRP水平明显升高,升高程度与ACS类型有关,N-proBNP与hs-CRP水平呈显著正相关,均为患者病情诊断、预后判定重要指标。

Objective To observe the changes of levels of N-terminal pro-B-type natriuretic peptide(N-proBNP)and highsensitivity C-reactive protein(hs-CRP)in patients with acute coronary syndrome(ACS)and to analyze their correlation.Methods 22 patients with stable angina pectoris(SAP)admitted to our hospital were enrolled in SAP group,and 58 patients with ACS were divided into acute myocardial infarction(AMI)group and unstable angina(UA)group according to the differences of ACS.And another 80 subjects with healthy examination at the same time period were included in control group.Serum N-proBNP and hs-CRP levels were compared among four groups,and the correlation between N-proBNP and hs-CRP was analyzed.Results The levels of serum N-proBNP and hs-CRP in the four groups showed AMI group>UA group>SAP group>control group(P<0.05).Correlation analysis showed that serum N-proBNP level in patients with ACS was positively correlated with hs-CRP level(r=0.817,P<0.05).Conclusion The levels of serum N-proBNP and hs-CRP in patients with ACS are significantly increased,and the increases are related to ACS types.N-proBNP is significantly positively correlated with hs-CRP level,and they were important indicators for the diagnosis od disease and prognosis of patients.