长链非编码RNA在甲状腺癌中的研究进展

Research progress of long non-coding RNAs in thyroid cancer

甲状腺癌是近年来发病率快速增长的内分泌肿瘤。人类恶性肿瘤与环境因素密切相关,环境改变可诱导机体内某些致病基因发生变化,从而促进了疾病的发生。在对人类的基因转录组的研究过程中,发现了一类长度超过200个核苷酸的非编码RNA,即长链非编码RNA(LncRNAs ),其通过调节基因表达参与细胞分化、增殖、凋亡、迁移和侵袭等肿瘤的发生发展。越来越多的研究发现LncRNAs与甲状腺癌关系密切,许多LncRNAs对甲状腺有致癌或抑癌作用,但其具体功能和作用机制尚不明确。笔者对LncRNAs在甲状腺癌中的最新研究进展进行综述,为探讨LncRNAs在甲状腺癌中的作用机制及其临床应用价值提供依据。

Thyroid cancer is an endocrine tumor with a rapid increase in prevalence in recent years. Human malignant tumors are closely related to environmental factors. Environmental changes can induce changes in certain pathogenic genes in the body, thus promoting the occurrence of diseases. A class of non-coding RNAs over 200 nucleotides in length, known as long non-coding RNAs(LncRNAs), has been found in human transcriptomes. LncRNAs are non-coding RNAs over 200 nucleotides in length that are involved in tumorigenesis, cell proliferation, proliferation, apoptosis, migration, and invasion by regulating gene expression. More and more studies have found that LncRNAs are closely related to thyroid cancer. Many LncRNAs have carcinogenic or tumor suppressive effects on the thyroid gland, but its function and mechanism are still unclear. This article reviews the recent research progress of LncRNAs in thyroid cancer, and provides a basis for exploring the mechanism of LncRNAs in thyroid cancer and its clinical application.