摘要
白细胞介素(IL)-22是IL-10家族的成员之一.目前,对于IL-22在2型糖尿病(T2DM)患者外周血清中的表达水平仍然存在着争议.IL-22可以通过信号转导与转录激活因子(STAT)3途径调节Reg基因的表达,诱导β细胞再生,也可以通过促进高血糖状态下角质形成细胞的增殖和损伤修复,改善T2DM慢性并发症.进一步了解IL-22在T2DM及其并发症中的作用,可为寻找T2DM及其并发症新的诊断及治疗方法提供帮助.
Interleukin ( IL)-22 is a member of the IL-10 family. Currently, the expression level of IL-22 in peripheral blood serum of patients with type 2 diabetes ( T2DM) is still controversial. IL-22 can regulate the expression of Reg gene through the signal transduction and activators of transcription(STAT)3 pathway to induceβcell regeneration, and it can also improve the chronic complications of T2DM by promo-ting the proliferation and damage repairment of keratinocytes in the condition of hyperglycemia. Further un-derstanding of the role of IL-22 in T2DM and its complications can help to find new diagnostic and therapeu-tic methods for T2DM and its complications.
作者
钱瑶
曾姣娥
薛君力
Qian Yao;Zeng Jiaoe;Xue Junli(Medical College,Yangtze University,Jingzhou 434020,China;Department of Endocrinology,Jingzhou Central Hospital,Jingzhou 434020,China)
出处
《国际内分泌代谢杂志》
2019年第5期337-340,共4页
International Journal of Endocrinology and Metabolism
基金
湖北省自然科学基金(2017CPB736).
