多囊卵巢综合征与肠道菌群

Polycystic ovary syndrome and gut microbiota

多囊卵巢综合征(PCOS)是育龄女性最常见的内分泌疾病,其病因复杂,发病机制尚未完全明确.肠道菌群作为与人体共生的巨大微生物群落,已证实与多种代谢性疾病密切相关.目前研究发现,肠道菌群可能通过损伤肠道黏膜屏障、改变菌群组成、影响肠-脑轴等机制,与PCOS的高雄激素血症、胰岛素抵抗、肥胖、慢性炎性反应等临床表现紧密联系,对其深入研究可能为PCOS患者的临床治疗提供新思路.

Polycystic ovary syndrome ( PCOS) is the most common endocrine disease in women of childbearing age, but its etiology is complex and the pathogenesis is not completely clear. The gut microbiota, as a large symbioticmicrobial community in human body, has been shown to be closely related to a variety of metabolic diseases. At present, many studies found that the gut microbiota may be closely related to the clinical manifestations of patients with PCOS, such as hyperandrogenism, insulin resistance, obesity, and chronic inflammation, by injuring the intestinal mucosal barrier, changing the microbial composition and the gut-brain axis. It is believed that further study may provide new ideas for clinical treatment of patients with PCOS.